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Indian origin researchers link fat buildup to impaired brain immunity in Alzheimer’s
A Purdue-led study shows that microglia near amyloid beta plaques — the toxic protein deposits linked to Alzheimer’s — accumulate large amounts of fat.
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Pranavi Sharma - Wed, 10, Sep 2025
- 02:58 EDT
- 9
Gaurav Chopra and graduate students Palak Manchanda and Priya Prakash led research on how fat disables the brain’s immune shield in Alzheimer’s disease. / Purdue University
Indian-origin professor Gaurav Chopra and graduate students Palak Manchanda and Priya Prakash at Purdue University have led research showing how fat buildup in the brain’s immune cells, known as microglia, disables their ability to fight Alzheimer’s disease. The findings were published in Immunity on Sept.9.
The study shows that microglia near amyloid beta plaques — the toxic protein deposits linked to Alzheimer’s — accumulate large amounts of fat. These fat-laden cells lose their ability to clear harmful proteins and maintain brain health.
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