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Pallavi Gopal leads Yale lab studying key protein behind ALS, dementia
Her team studies TDP-43 movement in neurons to uncover how its mutations trigger ALS and dementia before symptoms appear.
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Pranavi Sharma - Mon, 23, Jun 2025
- 03:14 EDT
- 20
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Gopal Lab members, from left, Smita Mathew, PhD, Pallavi Gopal, MD, PhD, Aditi Naskar, PhD, and Sonali Vishal, PhD. / Yale School of Medicine
Pallavi Gopal, a physician-scientist and associate professor of pathology at Yale School of Medicine, is leading efforts to better understand the role of a protein called TDP-43 in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
At the Gopal Lab in Yale Pathology, Gopal and her team are investigating how mutations in TDP-43, a protein that binds to RNA and DNA inside cells, may disrupt normal brain cell function and contribute to disease. “We study this RNA binding protein because there’s a lot of genetic and cell biological evidence that this is an important part of the pathogenesis of those two diseases,” the lab told Yale School of Medicine.
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