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Indian-origin team at Buffalo finds how harmful RNA clumps form, dissolve
A UB study shows repeat RNAs form persistent, disease-linked clumps. Researchers claim to have found a targeted RNA tool that can break them apart.
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Pranavi Sharma - Tue, 08, Jul 2025
- 01:20 EDT
- 26
RNA clusters, Priya Banerjee, Tharun Selvam Mahendran (below right). / University of Buffalo
A research team, led by Indian-origin scientist Priya Banerjee and his student Tharun Selvam Mahendran at the University at Buffalo, has discovered how harmful RNA clusters form inside cells—and how they can be broken apart. The findings, published in Nature Chemistry, could offer new insights into treating neurological disorders such as ALS and Huntington’s disease.
The study shows that repeat RNAs, which are linked to such diseases, form solid-like aggregates inside biomolecular condensates—droplet-like cellular structures made of proteins and nucleic acids. These RNA clusters have long been believed to be irreversible and damaging to brain function.
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